Meeting with Dr Pascal Douek

DIVIE met with Dr. Pascal Douek, physician, patient expert and author of “Medical Cannabis, a New Chance” at Solar Editions. He agreed to answer our questions.


Hello Doctor, can you explain us precisely what Cannabidiol (CBD) is?

Dr. Douek: In the cannabis plant (Cannabis Sativa L.), there are many active substances called phytocannnabinoids. Of these, the 2 best known are tetrahydrocannabidiol (THC) which is the psychoactive substance and cannabidiol (CBD) which has no psychoactive or addictive effect.

These two substances act on the endocannabinoid system (composed of CB1, CB2 and endocannabinoid molecules) that was discovered in the late 1990s.

The CBD was first isolated in 1940. It is present, like all phytocannnabinoids, in the cannabis flower.

It activates the endocannabinoid system and has many actions: anxiolytic (reduction of anxiety), anticonvulsant (reduction of seizures of epilepsy), analgesic, anti-inflammatory, antiemetic (against nausea and vomiting) and neuroprotective (protection of nerve cells).

In light doses, CBD has a well-being effect: it relaxes, reduces anxiety and improve sleep.

At higher doses, it has anticonvulsant medical properties. A CBD-based drug is indicated in some forms of severe epilepsy.


What effects Cannabidiol users can expect?

The use of Cannabidiol for non-medical purposes is of interesting for its well-being effects. Its soothing action improve sleep and reduces anxiety.


Why are you in favour of a regulatory framework around cannabidiol, as in some of our European neighbours? And do you think Cannabidiol oils should be sold in pharmacies?

Cannabidiol used in light doses is devoid of psychoactive and addictive effects. It also has a good tolerance.

But, today the market is not yet regulated and the quality of products marketed in CBD shops or on ecommerce sites is not controlled.

There is a real stake in this regulation. Consumers must have quality guaranted on marketed products. The doses of CBD advertised on the packaging must be able to be verified. The nature and origin of CBD must be known by the consumer. The presence of THC, terpenes and flavonoids should also be specified. Finally, the presence of additives should be mentioned.

Once this market is regulated, CBD should be able to enter pharmacies. With oils but also with dietary supplements.


Thank you, Doctor.

Dr Pascal Douek, “Medical Cannabis, a New Chance” at Solar Editions.